I'm a knitter and crocheter. Most afghans machine wash very well- if you can manage to fit it into your machine even for spinning the excess water out. The main thing you would probably want to watch out for is if the afghan is made of wool yarn. Washing wool causes it to "felt" which is interesting, but will likely ruin the look of the afghan.
All the afghans I've crocheted (out of synthetic yarn), I just machine wash gently and dry on low- most yarn is designed to handle that kind of washing.
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